Chemical biology of isoprenylation/methylation.
نویسنده
چکیده
682 25 Griinler, J., Olsson, J. M. and Dallner, G. (1995) 29 Reiss, Y., Brown, M. S. and Goldstein, J. I , . (1992) FEBS Lett. 358, 230-232 26 Shipton, C. A., Parmryd, I., Swiezewska, E., 30 Forman, €3. M., Goode, I<., Chen, J., Oro, A. E., Andersson, B. and Dallner, G. (1995) J. Biol. Bradley, D. J., Perlmann, ‘I-., Noonan, I). J., Burka, Chem. 270, 566-572 1, . T., McMorris, ‘I7., I,amph, W. W., Evans, K. M. 27 Repko, E. M. and Maltese, W. A. (1989) J. Biol. and Weinberger, C. (1995) Cell 81, 687-093 Chem. 264,9945-9952 28 Parmryd, I., Shipton, C. A., Swiezewska, E., Andersson, B. and Dallner, G. (1996) Eur. J. Biochem. 234. 723-731 J. Biol. Chem. 267, 6403-6408
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 24 3 شماره
صفحات -
تاریخ انتشار 1996